As a sequel, Capcom vs. SNK 2 – Mark of the Millennium 2001 comes with some new game features. For example, instead of maintaining the same ratio system in which characters have specific ratio, players are given the freedom to distribute the ratio to the chosen characters as they see fit.

The game offers the fun of close quarter combats between characters from SNK and Capcom fighting series. Many of the characters come from Street Fighter series such as Guile, Blanka, Ken Master, Edmond Honda, and Cammy White.